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Istradefylline 40 mg/day elevated peak levels and AUC of CYP3A4 substrates in medical trials. This influence wasn't observed with istradefylline 20 mg/working day. Take into consideration dose reduction of sensitive CYP3A4 substrates.Hepatic impairment: In patients with significant hepatic impairment, modafinil dose ought to be lessened by just on